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| Content | |
|---|---|
| Description | Stem Cell Lineage Database for the annotation of cell types and developmental lineages. |
| Contact | |
| Research center | University of Connecticut |
| Laboratory | Department of Molecular & Cell Biology |
| Authors | Edward E Hemphill |
| Primary citation | Hemphill & al. (2011)[1] |
| Release date | 2010 |
| Access | |
| Website | http://scld.mcb.uconn.edu |
The Stem Cell Lineage Database (SCLD) is a database of resources used to identify cell lineages.[1]
The Stem Cell Lineage Database (SCLD) was created by the University of Connecticut in order to have a more user friendly approach to retrieve and share data. The purpose of the Stem Cell Lineage Database is to consolidate the three key components into a database that is accessible and capable of storing information "about cell type gene expression, cell lineage maps and stem cell differentiation protocols for both human and mouse stem cells and endogenous developmental lineages".[1] One of the major factors that separates SCLD from other stem cell databases is that it allows users to edit information pertaining to cell types, markers, and lineages. The database allows user to update information found from the organic developmental stages and it also allows users to discuss experimental practices that altered the stem cells.
Stem cells are cells in the body that can divide indefinitely in a culture and can be formulated into specialized cells.[1][2] In biological research, these cells have become a subject of extensive research. With these cells, scientists will be able to better understand how these cells are differentiated by the process of turning on and off genes. Through this research, scientists will be able to better understand certain diseases such as cancer and how these diseases arise.
As stem cell research continues, scientists will need a database to store and share their information and research. Three key components are necessary for this database to be effective: cell type-specific gene expression profiles, anatomical and developmental relationships between cells and tissues and signals important for development and differentiation of stem cells to mature cell types.[1]
- ^ a b c d e Hemphill, E. E.; Dharia, A. P.; Lee, C.; Jakuba, C. M.; Gibson, J. D.; Kolling Fw, F. W.; Nelson, C. E. (2010). "SCLD: A stem cell lineage database for the annotation of cell types and developmental lineages". Nucleic Acids Research. 39 (Database issue): D525–33. doi:10.1093/nar/gkq941. PMC 3013792. PMID 20972216.
- ^ Bethesda. "Stem Cell Basics". Stem Cell Information. Retrieved 13 November 2013.